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Hyperthermostable mutants of Bacillus licheniformis alpha-amylase: thermodynamic studies and structural interpretation
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. These findings are supported by MD simulations that suggest that the flexibility of protein residues may either decrease or increase upon ligand-binding (9)
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. To our knowledge, this study represents the first application of pressure to membrane-bound proteins under conditions where the proteins are bound to the membrane surface
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. In their lipid-free state, apoA-2 and other exchangeable apolipoproteins form marginally stable molten globule with substantial helix content but nonspecific tertiary structures (Gursky and Atkinson, 1996a,b)
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. Formation of spherical, reconstituted high density lipoproteins containing both apolipoproteins A-I and A-II is mediated by lecithin:cholesterol acyltransferase
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. Studies on the pathogenic amyloidogenic self-assembly of proteins are showing that different transient morphological forms of aggregates have varying neurotoxicity levels (e
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- Theory predicts that ensemble-averaged internal distances will scale like ensemble-averaged end-to-end distances such that [left angle bracket]R^sup 2^^sub ij^[right angle bracket]/([left angle bracket]R^sup 2^^sub e^[right angle bracket]|i - j|) = [left angle bracket](r^sub i^ - r^sub j^)^sup 2^[right angle bracket]/([left angle bracket]R^sup 2^^sub e^[right angle bracket]|i - j|)~1 (39)
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