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The discovery and characterization of partially folded states known as molten globules (MG) were important to our understanding of protein folding mechanisms (Dolgikh et al
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- The I [arrow right] A transition, which was referred to as the dominant unfolding process above, began at around 70°C and the midpoint of the transition (T^sub 1/2^) occurred at ~84°C (see Table 1)
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. 8 B shows that it is in fact impossible to find room for small or large cavities unless the cavity is located sufficiently far from the center of mass of the folded protein
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