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Since the frequency of the solvent-exposed secondary structures is smaller than the buried ones (44,45), the above sequential events could be interpreted as follows: the unfolding of the solvent-exposed ß-sheet structures is the earliest event, followed by the formation of aggregates, and finally the unfolding of the other native structures
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. 7 a demonstrates the dimer of the modeled glycoprotein with one covalently attached oligomannose chain
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. This helix-loop-helix motif folded against the ban-el, covering a hydrophobic patch (which includes Tip^sup 461^): the motif was linked to the barrel by two salt bridges, namely, Arg^sup 537^-Asp^sup 467^ and Arg^sup 546^-Asp^sup 459^ (Fig
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. 6 [Angstrom] when the backbones from N- and C-terminal domains from eight other CaM molecules were compared (data not shown)
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