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The latter is a model for a soft, Gaussian coil with large-scale, albeit uncorrelated
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. This motion may or may not be superimposed onto varying degrees of picosecond-timescale motion
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. Not only is its flexibility reduced, but its configuration is also altered
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. As the MIT economist Peter Temin recounted in a 1983 study published by the Journal of Health Economics, prescriptions were simply a practical way for doctors to communicate with pharmacists
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. Changes to this second edition include chapter examples, summaries, key terms, and boxed readings, along with expanded material on topics such as statistical theory, screening and transforming data, and ANOVA
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. (NOTE: The recommended dosages are for typical extracts and formulations; when using commercial products, follow package directions
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. We plotted these coefficients in graphs to provide a visual expression of the likelihood that the postgain effects are influenced by unmeasured factors in the preperiod (i
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. 16 In the binge-type pattern of use, the initial positive effects may be followed by restlessness, irritability, and possibly paranoid psychoses that reinforce the continued use of the drug to maintain the 'high' which eventually will lead to tolerance and psychological dependence
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- These folding intermediates exhibited flexible tertiary structures and nativelike secondary structures
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. Do eyeless fish in caves develop a more efficient neural network than eyed fish riving in the dark? We think the answer is yes, because functional eyes in darkness do not stop sending information to the brain: "I detect no light
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. Reversibility of the thermal transition was examined by reheating the samples after cooling from the first scan
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. The observations that so many eukaryotic proteins are glycosylated and that N-linked glycosylation is more frequently observed in proteins suggest that N-linked glycans are a prime requisite for sustaining the structure-function equilibrium in many proteins (6)
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., close to the active-site gorge), while at the same time increasing fluctuations in some other part of the protein (see
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.Importantly, all probes show different kinetics, with varying amplitudes and rates during the reaction (Table 1)
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. Arrhenius analysis reveals two kinetic phases, a slower phase with E^sub a,slow^ = 60 kcal/mol and a faster phase with E^sub a,fast^ = 22 kcal/mol
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. The microscope was coupled to an AS-12 E-scanner (13-µm) and an Extender Electronics Module EX-II (Digital Instruments, Santa Barbara, CA), which allows acquisition of phase images
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. Nonetheless, it underlines the importance for overall folding rates of free-energy structures along a folding pathway, in which successive fluctuations in entropy and energy create a sequence of intermediate states
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. Aortic fen-phen valvulopathy was evident in 2 patterns (Figure 3)
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.Thermal effects are understood, says Engels, in terms of their impact on molecular structure and the corresponding impact on drug efficacy
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. New York: Kluwer Academic/Plenum Publishers, 2000:235
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