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Mol Cell 2004; 14:277-287(17) Gresham HD, Dale BM, Potter JW, et al
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. Further, their internal flexibility increases drastically from compact WT and C3A/C26A to the cavity-forming mutants I7S and F110S
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. In contrast to the 60°C incubation, in which a fibril concentration increase of ~1:4 (235 fibers versus 325 fibers) can be determined in the time period between 1 day and 1 week, a noteworthy fibril concentration change at 70°C in the same period does not take place
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. New York: Van Nostrand Reinhold, 1982:130-174
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- Using these procedures, the energetics and pathways of folding, as well as the existence of transient intermediate states between unfolded and fully folded polypeptides, have been characterized for a number of proteins (for a collection of reviews, see Creighton, 1992; Pain, 1994)
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